ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands
نویسندگان
چکیده
منابع مشابه
Identification of novel ligands for thiamine pyrophosphate (TPP) riboswitches.
Riboswitches are regions of mRNA to which a metabolite binds in the absence of proteins, resoulting in alteration of transcription, translation or splicing. The most widespread forms of riboswitches are those responsive to TPP (thiamine pyrophosphate) the active form of vitamin B1, thiamine. TPP-riboswitches have been found in all bacterial genomes examined, and are the only ones found in eukar...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2018
ISSN: 1552-4450,1552-4469
DOI: 10.1038/s41589-018-0114-4